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In a routine blood tests, elevated levels of B12 are found in approximately 815% of patients referred for the measurement [26, 27]

2022;34(7):e2107054

The likely-resulting endotoxemia from intestinal barrier dysfunction stimulates toll-like receptor 4 (TLR4) in Kupffer cells to produce NADPH-oxidase (NOX)-dependent ROS [213] and activate HSCs, leading to fibrosis [144, 219]